June 5, 2020 Conference


Topographic Variation of Retinal and Choroidal Vascular Density in Normal Eyes using Optical Coherence Tomography Angiography

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Michael Park, Yale University Department of Ophthalmology and Visual Sciences (Presenter)
Dr. Benjamin Young, Yale University Department of Ophthalmology and Visual Sciences
Mr. Liangbo (Linus) Shen, Yale School of Medicine, Yale University
Dr. Ron Adelman, Yale University Eye Center
Dr. Lucian Del Priore
PURPOSE: Optical coherence tomography angiography has become widely used by clinicians and researchers to qualitatively and quantitatively describe the retinal vasculature in normal eyes and eyes with chorioretinal pathology, including diabetic retinopathy, macular degeneration, and retinal artery and vein occlusions. A detailed study establishing a normative vascular topography map for each of the vascular layers has not yet been done. This study was performed to establish a normative, continuous vessel density topography map of the superficial and deep vascular plexus, as well as the choriocapillaris layer in normal eyes using OCT angiography imaging. DESIGN: Retrospective cohort study METHODS: 8x8 mm OCT angiography images centered on the fovea from 14 normal eyes (13 patients) were analyzed. A continuous vessel density curve as a function of distance from foveal center was generated for the superficial and deep retinal vasculature, and the choriocapillaris layers. The transition point, defined as the point of greatest slope change, was determined for each of the density curves. We determined the vascular density along different meridians and used this data to determine the vessel density in the nasal, superior, temporal, inferior quadrants in all 3 layers. RESULTS: The transition point occurred at different distances from the foveal center for each layer, at 587.9 microns, 881.8 microns, and 1986.5 microns from foveal center for the superficial, deep, and choriocapillaris layers, respectively. For the superficial plexus, the nasal quadrant had the greatest vessel density (p<0.0008). For the deep plexus, the nasal, superior, and temporal quadrants had greater vessel density compared to the inferior quadrant (p<0.0091). For the choriocapillaris layer, the temporal quadrant had greater vessel density compared to the nasal and superior quadrants (p<0.0073) but was not significantly different than the inferior quadrant (p=0.2738). CONCLUSION: Our study provides a normative, continuous vessel density topography map using OCT angiography of normal eyes. This vascular density map may be a valuable tool to determine baseline values for these parameters, and to determine the changes in these parameters in different chorioretinal diseases.
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