June 5, 2020 Conference

  


TEST
Title
Evaluation of retinal nerve fiber layer, ganglion cell-inner plexiform layer, and optic nerve head in glaucoma suspects with varying myopia

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Author(s)
Gregg Miller, Tufts University School of Medicine (Presenter)
Dr. Abu-Qamar Omar, New England Eye Center- Tufts
Dr. Sarwat Salim, New England Eye Center - Tufts University School of Medicine
Abstract
Purpose: To assess the effect of myopia on retinal nerve fiber layer (RNFL), ganglion cell-inner plexiform layer (GCIPL), and optic nerve head (ONH) parameters in glaucoma suspects. Methods: 76 eyes studied with Cirrus-HD OCT were divided into low (LM; n=27), moderate (MM; n=25), and high myopia (HM; n=24). OCT parameters were correlated with spherical equivalent (SE) and evaluated with area under the receiver operating characteristic (AUROC) curves. Results: In MM and HM, SE was positively correlated with thinning of average, minimum, and non-temporal GCIPL (p<0.05 for all) except for inferior in MM (p=0.15). In HM, the correlation was shown for average and non-temporal RNFL (p<0.05 for all) except for inferior (p=0.06). SE was not correlated with ONH parameters in MM or HM (p>0.05). The highest AUROCs for RNFL and GCIPL parameters were for superior (0.82) and superonasal (0.80) regions respectively, with comparable diagnostic ability (p=0.74). Conclusion: Myopia is associated with thinning of average RNFL, average and minimum GCIPL, and non-temporal parameters of both GCIPL and RNFL, warranting consideration of refractive status in glaucoma suspects. Acknowledgements: This research was supported, in part, by an RPB Challenge grant made to the Department of Ophthalmology, Tufts Medical Center.
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